Three New Sesquiterpenes from the Leaves of Aglaia elaeagnoidea with NO Inhibitory Activity.

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2024-11-10 DOI:10.1002/cbdv.202402159

Nguyen Huy Hoang, Do Thi Trang, Ngo Anh Bang, Pham Hai Yen, Duong Thi Dung, Nguyen Xuan Nhiem, Le Thi Huyen, Phan Thi Thanh Huong, Duong Thi Hai Yen, Bui Huu Tai, Phan Van Kiem

引用次数: 0

Abstract

Aglanoideas A-C (1-3), three undescribed sesquiterpenes and eleven known compounds (4-14) were isolated from the leaves of Aglaia elaeagnoidea. Their structures including absolute configurations were characterized by using IR, HR-ESI-MS, NMR, and experimental and calculating ECD methods. Compounds 3-5, and 7 showed moderate nitric oxide inhibitory activity with IC₅₀ values ranging from 53.7 to 72.5 μM.

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具有氮氧化物抑制活性的 Aglaia elaeagnoidea 叶中的三种新的倍半萜。

从 Aglaia elaeagnoidea 的叶子中分离出了 Aglanoideas A-C（1-3）、三种未被描述的倍半萜和十一种已知化合物（4-14）。利用红外光谱、HR-ESI-MS、核磁共振以及实验和计算 ECD 的方法对这些化合物的结构（包括绝对构型）进行了表征。化合物 3-5 和 7 显示出中等程度的一氧化氮抑制活性，IC50 值在 53.7 至 72.5 µM 之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.