Analysis of Swallowing Functional Preservation by Surgical Versus CRT After Induction Chemotherapy for Oropharyngeal Cancer.

IF 4.5 2区医学 Q1 ONCOLOGY

Cancers Pub Date : 2024-10-30 DOI:10.3390/cancers16213658

Yung-An Tsou, Wen-Dien Chang, Nai-Hsin Meng, Chun-Hung Hua

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引用次数: 0

Abstract

Objectives: This retrospective observational study investigated to determine whether surgery or chemoradiation therapy after induction chemotherapy leads to better swallow function for oropharyngeal cancer patients. Methods: We documented the treatment paths and results of 267 patients with oropharyngeal squamous cell cancer (OPSCC). By quantifying nasogastric (NG) tube usage, surgery after induction chemotherapy (IC-surgery), and chemoradiation therapy after induction chemotherapy (IC-CRT) could be compared to determine the effectiveness of each. Cancer stages were also recorded concerning treatment options. The differences in NG tube usage IC-surgery and IC-CRT groups were compared. The NG tube dependence rates were also presented. Results: The prognosis and tube dependence differed significantly between the two groups. The IC-surgery had a better prognosis compared to IC-CRT for oropharyngeal cancer. The findings indicated that NG tube dependence was greater in advanced tumor stage 4 compared to stages 1-3, and NG tube dependence rates were higher for patients who underwent chemoradiation therapy after induction chemotherapy. Swallowing function was better in the IC-surgery group compared to the IC-CRT group. Conclusions: Higher NG tube retention rates and NG dependence are found in OPSCC patients who choose CRT as their treatment and also in the advanced-stage group.

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口咽癌诱导化疗后手术与 CRT 的吞咽功能保存分析

研究目的这项回顾性观察研究旨在确定诱导化疗后手术或化疗放疗是否能改善口咽癌患者的吞咽功能。研究方法我们记录了 267 名口咽鳞状细胞癌（OPSCC）患者的治疗路径和结果。通过量化鼻胃（NG）管的使用情况，对诱导化疗后的手术（IC-手术）和诱导化疗后的化放疗（IC-CRT）进行比较，以确定各自的疗效。此外，还记录了与治疗方案有关的癌症分期。比较了 IC 手术组和 IC-CRT 组在使用 NG 管方面的差异。同时还列出了 NG 管依赖率。结果：两组患者的预后和对 NG 管的依赖程度差异显著。与 IC-CRT 相比，IC-手术治疗口咽癌的预后更好。研究结果表明，晚期肿瘤 4 期患者对 NG 管的依赖程度高于 1-3 期患者，诱导化疗后接受化学放疗的患者对 NG 管的依赖程度更高。与 IC-CRT 组相比，IC 手术组的吞咽功能更好。结论选择 CRT 治疗的 OPSCC 患者和晚期组患者的 NG 管留置率和 NG 依赖性较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancers Medicine-Oncology

CiteScore

8.00

自引率

9.60%

发文量

5371

审稿时长

18.07 days

期刊介绍： Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.