Role of iron in the treatment of sepsis.

IF 1.6 4区 医学 Q4 BIOPHYSICS
Biointerphases Pub Date : 2022-11-01 DOI:10.1116/6.0003879
Chenyang Zhang, Zhiyao Fang, Kaixuan Wang, Jia Wang, Xianyao Wan
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引用次数: 0

Abstract

Iron is an important microelement in human and microbial life activities. During the pathophysiological process of sepsis, iron metabolism changes and the body undergoes a series of changes to fight microbial infection. Meanwhile, alterations in iron metabolism during sepsis lead to the development of some diseases, such as transfusion-induced siderosis and anemia. In recent years, several studies have demonstrated the use of iron-chelating agents to fight microbial infections, and new antimicrobial agents have been developed using "Trojan horse" and siderophores immunity. In addition, the use of iron-based nanomaterials as drug delivery systems for gene delivery may be applied to the treatment of sepsis in the future. In this review, we describe the pathophysiological changes in the development and course of sepsis, focusing on the potential of iron in the treatment of sepsis.

铁在治疗败血症中的作用。
铁是人体和微生物生命活动中的重要微量元素。在败血症的病理生理过程中,铁代谢会发生变化,机体为抵抗微生物感染会发生一系列变化。同时,败血症期间铁代谢的改变会导致一些疾病的发生,如输血引起的淤血和贫血。近年来,一些研究表明,铁螯合剂可用于抗微生物感染,利用 "特洛伊木马 "和嗜蛛网膜免疫开发出了新的抗菌剂。此外,利用铁基纳米材料作为药物递送系统进行基因递送,未来可能会应用于败血症的治疗。在这篇综述中,我们描述了败血症发生和发展过程中的病理生理变化,重点探讨了铁在败血症治疗中的潜力。
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来源期刊
Biointerphases
Biointerphases 生物-材料科学:生物材料
自引率
0.00%
发文量
35
期刊介绍: Biointerphases emphasizes quantitative characterization of biomaterials and biological interfaces. As an interdisciplinary journal, a strong foundation of chemistry, physics, biology, engineering, theory, and/or modelling is incorporated into originated articles, reviews, and opinionated essays. In addition to regular submissions, the journal regularly features In Focus sections, targeted on specific topics and edited by experts in the field. Biointerphases is an international journal with excellence in scientific peer-review. Biointerphases is indexed in PubMed and the Science Citation Index (Clarivate Analytics). Accepted papers appear online immediately after proof processing and are uploaded to key citation sources daily. The journal is based on a mixed subscription and open-access model: Typically, authors can publish without any page charges but if the authors wish to publish open access, they can do so for a modest fee. Topics include: bio-surface modification nano-bio interface protein-surface interactions cell-surface interactions in vivo and in vitro systems biofilms / biofouling biosensors / biodiagnostics bio on a chip coatings interface spectroscopy biotribology / biorheology molecular recognition ambient diagnostic methods interface modelling adhesion phenomena.
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