Association between miR-30 polymorphism and ischemic stroke in Chinese population.

IF 2.1 4区医学 Q3 GENETICS & HEREDITY

BMC Medical Genomics Pub Date : 2024-11-13 DOI:10.1186/s12920-024-02041-z

Yan-Ping Luo, Xi-Xi Gu, Chao Liu, Ying Huang, Li-Jiang Lu, Shu-Yu Zhang, Yu-Lin Yuan

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引用次数: 0

Abstract

Background: Ischemic stroke (IS) is a commonly seen cerebrovascular disease which seriously endangers the health of middle age and old people. However, its etiology and pathogenesis have not yet fully comprehended. miR-30 gene is a novel gene which may be involved in IS. However, no studies have investigated the relationship between IS and the single-nucleotide polymorphisms (SNPs) of miR-30. Therefore, this study examined the relationship between miR-30 polymorphisms (rs2222722, rs1192037, rs10095483 and rs16827546) and the risk of IS.

Methods: Totally 248 IS patients and 230 age-, sex- and race-matched controls were involved in this study. Based on SNPscan technique, four polymorphisms (rs2222722, rs1192037, rs10095483 and rs16827546) were genotyped.

Results: There exists a significant association between rs2222722 polymorphism and the risk of IS according to analyses of genotypes, models and alleles (GA vs. GG: adjusted OR = 1.616, 95% CI: 0.943-2.768, P = 0. 081); (AA vs. GG: adjusted OR = 2.447, 95% CI: 1.233-4.858, P = 0.011); dominant model: adjusted (OR = 1.806, 95% CI, 1.082-3.016, P = 0.024); (G vs. A: adjusted OR = 1.492, 95% CI: 1.148-1.939, P = 0.003). Besides, miR-30a expression was significantly higher in patients undergoing IS relative to that in controls (P < 0.05).

Conclusions: To conclude, the rs2222722 polymorphism of the miR-30 gene shows a significant relationship to elevate the risk of IS in Chinese population.

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中国人群中 miR-30 多态性与缺血性脑卒中的关系

背景：缺血性脑卒中（IS）是一种常见的脑血管疾病，严重危害中老年人的健康。miR-30 基因是一种可能与 IS 有关的新基因。然而，目前还没有研究探讨 IS 与 miR-30 的单核苷酸多态性（SNPs）之间的关系。因此，本研究探讨了 miR-30 多态性（rs2222722、rs1192037、rs10095483 和 rs16827546）与 IS 风险之间的关系：248名IS患者和230名年龄、性别和种族匹配的对照组参与了本研究。基于 SNPscan 技术，对四个多态性（rs2222722、rs1192037、rs10095483 和 rs16827546）进行了基因分型：根据对基因型、模型和等位基因的分析，rs2222722 多态性与 IS 风险之间存在明显的关联（GA vs. GG：调整 OR = 1.616，95% CI：0.943-2.768，P = 0. 081）；（AA vs. GG：调整 OR = 2.616，95% CI：0.943-2.768，P = 0.GG：调整后 OR = 2.447，95% CI：1.233-4.858，P = 0.011）；显性模型：调整后（OR = 1.806，95% CI：1.082-3.016，P = 0.024）；（G vs. A：调整后 OR = 1.492，95% CI：1.148-1.939，P = 0.003）。此外，IS 患者的 miR-30a 表达明显高于对照组（P 结论：IS 患者的 miR-30a 表达明显高于对照组）：总之，miR-30 基因的 rs2222722 多态性与中国人群 IS 风险的升高有显著关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Genomics 医学-遗传学

CiteScore

3.90

自引率

0.00%

发文量

243

审稿时长

3.5 months

期刊介绍： BMC Medical Genomics is an open access journal publishing original peer-reviewed research articles in all aspects of functional genomics, genome structure, genome-scale population genetics, epigenomics, proteomics, systems analysis, and pharmacogenomics in relation to human health and disease.