Gastrointestinal LCH: a rare manifestation of Langerhans cell histiocytosis.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL

Annals of Medicine and Surgery Pub Date : 2024-09-30 eCollection Date: 2024-11-01 DOI:10.1097/MS9.0000000000002607

Ishwor Thapaliya, Bishal Basnet, Dilip Sharma Banjade, Adesh Kantha, Sujan Mijar

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Abstract

Introduction: Langerhans cell histiocytosis (LCH) is a rare neoplasm marked by the proliferation of Langerhans cells, primarily affecting children under 2 years old. Gastrointestinal (GI) involvement in LCH is uncommon and often part of widespread disease.

Case presentation: We report a 16-year-old female with a history of LCH, previously treated with 6-mercaptopurine and vinblastine, who presented with bloody diarrhoea, abdominal pain, and vomiting. Examination revealed hypopigmented skin lesions, lymphadenopathy, and hepatosplenomegaly. Laboratory tests indicated anaemia and eosinophilia, and colonoscopy was suggestive of GI LCH.

Discussion: Gastrointestinal LCH often presents with nonspecific symptoms. It is crucial to maintain a high degree of suspicion for GI LCH in atypical GI presentations, as treatment outcomes can be challenging if diagnosed late or misdiagnosed.

Conclusion: GI symptoms in LCH are rare but may occur in isolation. Early diagnosis and treatment are crucial to reduce morbidity and improve prognosis.

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胃肠道 LCH：朗格汉斯细胞组织细胞增生症的一种罕见表现。

简介朗格汉斯细胞组织细胞增生症（Langerhans cell histiocytosis，LCH）是一种以朗格汉斯细胞增生为特征的罕见肿瘤，主要影响两岁以下儿童。朗格汉斯细胞组织细胞增生症的胃肠道（GI）受累并不常见，通常是广泛发病的一部分：我们报告了一名 16 岁女性的 LCH 病史，她曾接受过 6-巯基嘌呤和长春新碱治疗，并出现血性腹泻、腹痛和呕吐。检查发现皮肤色素减退、淋巴结肿大和肝脾肿大。实验室检查显示贫血和嗜酸性粒细胞增多，结肠镜检查提示消化道LCH：讨论：消化道 LCH 通常表现为非特异性症状。讨论：胃肠道 LCH 常常表现为非特异性症状，在出现不典型的消化道症状时，高度怀疑胃肠道 LCH 至关重要，因为如果诊断过晚或误诊，治疗效果可能会受到挑战：结论：LCH的消化道症状很少见，但可能单独出现。早期诊断和治疗对于降低发病率和改善预后至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Medicine and Surgery MEDICINE, GENERAL & INTERNAL-

自引率

5.90%

发文量

1665