The Treatment of Primary Lymphoepithelioma-Like Carcinoma in the Head and Neck and Nasopharyngeal Carcinoma

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2024-11-14 DOI:10.1002/cam4.70389

Qiaohong Lin, Mingyuan Du, Shida Yan, Xing Zhang, Xiyuan Li, Ying Zhang, Shiting Zhang, Shuwei Chen, Ming Song

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引用次数: 0

Abstract

Background

An uncommon cancer, lymphoepithelioma-like carcinoma (LELC) resembles undifferentiated nasopharyngeal carcinoma (NPC) histologically. The aim is mainly to introduce the diagnosis and treatment of LELC and compare it with NPC in our descriptive study.

Methods

A total of 278 patients with NPC and 157 patients with head and neck LELC had their medical records examined in this study. The propensity score matching (PSM) approach was employed to attain a 1:1 match between the LELC and NPC groups. Kaplan–Meier analysis was performed for overall survival (OS) of LELC and NPC. To determine their predictive values for OS, univariate and multivariate Cox regression analyses with significant survival differences (p < 0.05) were carried out.

Results

Similar to NPC, 107 (68.2%) LELC cases had Epstein–Barr virus (EBV) infection. LELC of the parotid glands was present in nearly 46.5% of patients with head and neck LELC. Most patients were treated with surgery with neck dissection. After PSM, LELC had similar 5-year OS rates to NPC (81.6% vs. 79.0%). LELC was less prone to distant metastasis compared to NPC. Age, T stage, N stage, and distant metastases were found to be substantially correlated with the outcome of LELC, according to the multivariate Cox regression analysis (p < 0.05).

Conclusions

EBV infection in the head and neck has been associated with LELC and NPC. When compared to NPC, LELC is more likely to arise in the salivary glands and has a lower incidence of distant metastasis. Surgery with neck dissection is the primary treatment for LELC.

Abstract Image

查看原文本刊更多论文

头颈部原发性淋巴上皮瘤样癌和鼻咽癌的治疗。

背景：淋巴上皮瘤样癌症（LELC）是一种不常见的癌症，在组织学上类似于未分化鼻咽癌（NPC）。本研究的目的主要是介绍淋巴上皮瘤样癌的诊断和治疗，并将其与鼻咽癌进行比较：本研究共检查了 278 名鼻咽癌患者和 157 名头颈部 LELC 患者的病历。采用倾向得分匹配法（PSM）使LELC组和NPC组达到1:1匹配。对LELC和NPC的总生存期（OS）进行了Kaplan-Meier分析。为了确定它们对OS的预测值，进行了单变量和多变量Cox回归分析，结果显示生存率存在显著差异（p）：与鼻咽癌相似，107 例（68.2%）腮腺淋巴结核患者也感染了爱泼斯坦-巴氏病毒（EBV）。近46.5%的头颈部LELC患者存在腮腺LELC。大多数患者接受了颈部切除手术治疗。PSM术后，LELC的5年生存率与NPC相似（81.6%对79.0%）。与鼻咽癌相比，LELC不易发生远处转移。多变量考克斯回归分析发现，年龄、T期、N期和远处转移与LELC的预后密切相关（P结论）：头颈部的EB病毒感染与LELC和鼻咽癌有关。与鼻咽癌相比，LELC 更可能发生在唾液腺，远处转移的发生率较低。颈部切除手术是治疗 LELC 的主要方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.