Advanced Preparation Methods and Biomedical Applications of Single-Atom Nanozymes.

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2024-11-13 DOI:10.1021/acsbiomaterials.4c01530

Chun-Nan Zhu, Xin Chen, Yong-Qiang Xu, Fei Wang, Dong-Yun Zheng, Chao Liu, Xue-Hao Zhang, Yu Yi, Dong-Bing Cheng

引用次数: 0

Abstract

Metal nanoparticles with inherent defects can harness biomolecules to catalyze reactions within living organisms, thereby accelerating the advancement of multifunctional diagnostic and therapeutic technologies. In the quest for superior catalytic efficiency and selectivity, atomically dispersed single-atom nanozymes (SANzymes) have garnered significant interest recently. This review concentrates on the development of SANzymes, addressing potential challenges such as fabrication strategies, surface engineering, and structural characteristics. Notably, we elucidate the catalytic mechanisms behind some key reactions to facilitate the biomedical application of SANzymes. The diverse biomedical uses of SANzymes including in cancer therapy, wound disinfection, biosensing, and oxidative stress cytoprotection are comprehensively summarized, revealing the link between material structure and catalytic performance. Lastly, we explore the future prospects of SANzymes in biomedical fields.

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单原子纳米酶的先进制备方法和生物医学应用。

具有固有缺陷的金属纳米粒子可以利用生物分子催化生物体内的反应，从而加速多功能诊断和治疗技术的发展。为了追求更高的催化效率和选择性，原子分散的单原子纳米酶（SANzymes）最近引起了人们的极大兴趣。这篇综述集中探讨了 SANzymes 的开发，解决了制造策略、表面工程和结构特征等潜在挑战。值得注意的是，我们阐明了一些关键反应背后的催化机理，以促进 SANzymes 的生物医学应用。我们全面总结了 SANzymes 在癌症治疗、伤口消毒、生物传感和氧化应激细胞保护等方面的多种生物医学用途，揭示了材料结构与催化性能之间的联系。最后，我们探讨了 SANzymes 在生物医学领域的未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture