Biomarker-based high-throughput sperm phenotyping: Andrology in the age of precision medicine and agriculture

IF 2.2 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal Reproduction Science Pub Date : 2024-11-08 DOI:10.1016/j.anireprosci.2024.107636

Filip Tirpak , Lauren E. Hamilton , Robert D. Schnabel , Peter Sutovsky

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引用次数: 0

Abstract

Reproductive efficiency is crucial for animal agriculture. This economically important aspect can be influenced by environmental burdens, nutritional imbalance, and gonadal or gametic malformations of genetic origin. Successful implementation of genomic-driven selective breeding in cattle depends on the reproductive performance of artificial insemination (AI) sires with valuable genomic production traits. Reproduction is traditionally viewed as a complex set of polygenic traits that are negatively impacted by using a small number of often closely related sires selected for AI due to their superior genetics. Despite recent progress, it remains difficult to define relationships between sire genome and variation in sperm phenotypes, even though several types of heritable, non-compensable sperm defects have been identified. In this review, we discuss the concept of sperm quality biomarker discovery and genomics of male fertility. We also outline a multidisciplinary genome-to-phenome approach for investigating heritable mutations and their impacts on bull fertility, sperm phenotypes and paternal contributions to early pregnancy. High-precision phenotyping requires novel, state-of-the-art instrumentation for sperm quality evaluation and development of new biomarkers of sperm quality in farm animals, with potential for incorporation into andrology-specific machine learning protocols and translation to human andrology. We conclude that reproduction is a complex phenotype that can be deciphered and explored for more precise male fertility evaluation and higher reproductive efficiency.

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基于生物标记的高通量精子表型分析：精准医疗和农业时代的男性学。

繁殖效率对畜牧业至关重要。环境负担、营养失衡、性腺或配子畸形等遗传因素都会影响这一重要的经济效益。基因组驱动的选择性育种能否成功实施，取决于人工授精（AI）母牛的繁殖性能是否具有有价值的基因组生产性状。传统上，繁殖被视为一组复杂的多基因性状，如果使用少数因遗传性能优异而被选作人工授精的亲缘关系密切的种公牛，这些性状就会受到负面影响。尽管最近取得了一些进展，但仍很难确定父本基因组与精子表型变异之间的关系，尽管已经确定了几种类型的可遗传、不可补偿的精子缺陷。在这篇综述中，我们讨论了精子质量生物标志物发现和男性生育力基因组学的概念。我们还概述了从基因组到表型组的多学科方法，用于研究遗传突变及其对公牛生育力、精子表型和父亲对早孕的贡献的影响。高精度表型分析需要新颖、先进的精子质量评估仪器，还需要开发新的农场动物精子质量生物标志物，并有可能将其纳入到男性学专用的机器学习协议中，并应用到人类男性学中。我们的结论是，繁殖是一个复杂的表型，可以通过解密和探索来实现更精确的雄性生育能力评估和更高的繁殖效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animal Reproduction Science 农林科学-奶制品与动物科学

CiteScore

4.50

自引率

9.10%

发文量

136

审稿时长

54 days

期刊介绍： Animal Reproduction Science publishes results from studies relating to reproduction and fertility in animals. This includes both fundamental research and applied studies, including management practices that increase our understanding of the biology and manipulation of reproduction. Manuscripts should go into depth in the mechanisms involved in the research reported, rather than a give a mere description of findings. The focus is on animals that are useful to humans including food- and fibre-producing; companion/recreational; captive; and endangered species including zoo animals, but excluding laboratory animals unless the results of the study provide new information that impacts the basic understanding of the biology or manipulation of reproduction. The journal''s scope includes the study of reproductive physiology and endocrinology, reproductive cycles, natural and artificial control of reproduction, preservation and use of gametes and embryos, pregnancy and parturition, infertility and sterility, diagnostic and therapeutic techniques. The Editorial Board of Animal Reproduction Science has decided not to publish papers in which there is an exclusive examination of the in vitro development of oocytes and embryos; however, there will be consideration of papers that include in vitro studies where the source of the oocytes and/or development of the embryos beyond the blastocyst stage is part of the experimental design.