Neuroleptic Malignant Syndrome in a 10-Month-Old Ex-Preterm Infant with Delirium.

IF 0.8 Q4 PEDIATRICS
AJP Reports Pub Date : 2024-11-12 eCollection Date: 2024-07-01 DOI:10.1055/a-2441-4217
Gloria Akuamoah-Boateng, Kayla A Buttafuoco, Courtney C Sutton, Brian P Hackett
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引用次数: 0

Abstract

In recent times, atypical antipsychotics are increasingly being used in the neonatal intensive care unit (NICU) for the management of neonatal delirium. As the recognition of delirium in NICU infants increases, caution should be exercised with use of antipsychotics for management, given associated adverse effects. Neuroleptic malignant syndrome (NMS) is a rare adverse drug reaction associated with exposure to antipsychotics and other antidopaminergic medications. Most reported cases of NMS in pediatric patients have been in older children on antipsychotic medications. We present a case of a 10-month-old former preterm infant who developed clinical signs suggestive of NMS after exposure to olanzapine for treatment of delirium. Our case report details the clinical course of this infant, delves into the condition, and outlines some useful lessons for the clinician in the identification and management of this rare but life-threatening adverse effect. Key Points NMS is a rare side effect of antipsychotic medications.Hyperthermia with mental status changes could be due to NMS.Antipsychotics should be used cautiously in infants.

一名 10 个月大的早产儿出现神经性恶性综合征并伴有谵妄。
近来,新生儿重症监护室(NICU)越来越多地使用非典型抗精神病药物来治疗新生儿谵妄。随着对新生儿重症监护室婴儿谵妄的认识不断提高,考虑到相关的不良反应,在使用抗精神病药物进行治疗时应谨慎行事。神经性恶性综合征(NMS)是一种罕见的药物不良反应,与接触抗精神病药物和其他抗多巴胺能药物有关。大多数报道的儿科 NMS 病例都发生在服用抗精神病药物的大龄儿童身上。我们报告了一例 10 个月大的前早产儿病例,该患者在接受奥氮平治疗谵妄后出现了提示 NMS 的临床症状。我们的病例报告详细介绍了该婴儿的临床病程,深入探讨了该病症,并概述了临床医生在识别和处理这种罕见但危及生命的不良反应方面的一些有用经验。要点 NMS是抗精神病药物的一种罕见副作用,伴有精神状态改变的高热可能是NMS所致,婴儿应慎用抗精神病药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AJP Reports
AJP Reports PEDIATRICS-
CiteScore
2.20
自引率
0.00%
发文量
30
审稿时长
12 weeks
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