Antibody–drug conjugates: prospects for the next generation

IF 6.5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Meriem Grairi , Marc Le Borgne
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引用次数: 0

Abstract

The concept of a ‘magic bullet’ was first introduced by Paul Ehrlich in the early 1900s, he foresaw the advent of targeted therapies and the specific killing of harmful cells and/or microorganisms. However, these therapies were only used in the clinic after the second half of the 20th century with the development of specific monoclonal antibodies. To date, 13 antibody–drug conjugates (ADCs) are commercially available. Many advances have been made by modifying one or several of the three main components of an ADC, namely the antibody, the cleavable or non-cleavable linker or the payload, and by integrating conjugation chemistry. Despite these efforts, some problems have emerged and thus limit their effectiveness. New strategies could overcome these problems and identify the next generation of ADC.
抗体-药物共轭物:下一代产品的前景。
20 世纪初,保罗-埃利希首次提出了 "灵丹妙药 "的概念,他预见了靶向疗法和特异性杀灭有害细胞和/或微生物疗法的出现。然而,随着特异性单克隆抗体的开发,这些疗法在 20 世纪下半叶之后才被应用于临床。迄今为止,已有 13 种抗体药物共轭物(ADC)在市场上销售。通过对 ADC 的三个主要成分(即抗体、可裂解或不可裂解连接体或有效载荷)中的一个或几个进行改良,以及通过整合共轭化学,ADC 取得了许多进展。尽管做出了这些努力,但还是出现了一些问题,从而限制了其有效性。新策略可以克服这些问题,并确定下一代 ADC。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Drug Discovery Today
Drug Discovery Today 医学-药学
CiteScore
14.80
自引率
2.70%
发文量
293
审稿时长
6 months
期刊介绍: Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.
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