Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, Japan

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2024-11-13 DOI:10.3201/eid3012.240538

Ayami Yoshikane, Hiroki Miura, Sayuri Shima, Masaaki Matsunaga, Soichiro Ishimaru, Yuki Higashimoto, Yoshiki Kawamura, Kei Kozawa, Akiko Yoshikawa, Akihiro Ueda, Atsuhiko Ota, Hirohisa Watanabe, Tatsuro Mutoh, Tetsushi Yoshikawa

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引用次数: 0

Abstract

An increase in the number of herpes zoster patients has been reported since universal varicella immunization was introduced, perhaps because of reduced opportunities for varicella patients to experience the natural booster effect caused by reexposure. We investigated recent trends of varicella zoster virus (VZV)–related central nervous system (CNS) infections at a university hospital in Japan. We enrolled patients with suspected CNS infection during 2013–2022 and tested cerebrospinal fluid samples by real-time PCR for DNA from 7 human herpesviruses. VZV DNA was the most commonly detected in 62 (10.2%) of 615 patients. Kulldorff’s circular spatial scan statistics demonstrated a significant temporal cluster of patients with VZV-related CNS infections during 2019–2022 (p = 0.008). Among persons with such infections, the percentage with aseptic meningitis was significantly higher during 2019–2022 (86.8%), when the temporal cluster of cases occurred, than during 2013–2018 (50.0%) (p = 0.0029).

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日本水痘带状疱疹病毒相关中枢神经系统感染成年患者人数增加

据报道，自水痘免疫接种普及以来，带状疱疹患者的人数有所增加，这可能是因为水痘患者经历再次接触所产生的自然强化效应的机会减少了。我们在日本一所大学医院调查了与水痘带状疱疹病毒（VZV）相关的中枢神经系统（CNS）感染的最新趋势。我们登记了 2013-2022 年间疑似中枢神经系统感染的患者，并通过实时 PCR 检测脑脊液样本中 7 种人类疱疹病毒的 DNA。在 615 例患者中，有 62 例（10.2%）最常检测到 VZV DNA。库尔多夫环形空间扫描统计显示，2019-2022 年期间，与 VZV 相关的中枢神经系统感染患者出现了明显的时间集群（p = 0.008）。在此类感染者中，2019-2022 年期间无菌性脑膜炎患者的比例（86.8%）明显高于 2013-2018 年期间的比例（50.0%）（p = 0.0029）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.