The association between insulin resistance and cytokines in adolescents with excess of adiposity

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2024-11-05 DOI:10.1016/j.cpcardiol.2024.102925

Robinson Ramírez-Vélez , María Correa-Rodríguez , Juan Carlos Calderón-González , Albeiro Dávila-Grisales , Katherine González-Ruíz , Jorge Enrique Correa-Bautista , Mikel Izquierdo

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引用次数: 0

Abstract

Background and aims

Increased adiposity has been directly associated with insulin resistance (IR), and cytokines released by adipose tissue seem to link adiposity to IR in youth. We used an antibody-based array to investigate the differential levels of serum cytokines according to insulin status in a cohort of overweight/obese and inactive adolescents and evaluated their potential associations with clinical and metabolic characteristics.

Methods and results

We performed a cross-sectional data analysis from 122 adolescents (11–17 years of age). We assessed body composition, cardiometabolic risk factors, biochemical variables, and physical fitness. The concentration of 55 cytokines was quantified in blood samples. The homeostasis model assessment insulin resistance (HOMA‐IR) and AST/ALT and TG/HDL ratios were calculated. IR adolescents as defined as HOMA-IR >2.5. The number of adolescents with IR in the study was 91 (66 % girls). In the IS group, after controlling for confounders, higher IL-15 levels were significantly associated with higher alanine aminotransferase levels and lower AST/ALT ratio, respectively (Ps<0.05). In the same line, there were significantly higher alanine aminotransferase levels and lower AST/ALT ratio, respectively, with FGF-9 (Ps<0.05). Likewise, higher alanine aminotransferase levels were significantly associated positively with HGF (p=0.045). Additionally, leptin levels are associated with six adiposity indexes (i.e., fat mass/height index, body fat, body mass index, android fat mass and gynoid fat mass) in overweight/obese adolescents with IR (Ps<0.05).

Conclusions

These data may provide novel insights into the pathogenic mechanisms underlying IR in youth, offering new targets for prevention.

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肥胖青少年的胰岛素抵抗与细胞因子之间的关系

背景和目的：肥胖的增加与胰岛素抵抗（IR）直接相关，而脂肪组织释放的细胞因子似乎与青少年的肥胖和IR有关。我们使用基于抗体的阵列研究了一组超重/肥胖和不运动青少年血清细胞因子水平与胰岛素状态的差异，并评估了它们与临床和代谢特征的潜在关联：我们对 122 名青少年（11-17 岁）进行了横断面数据分析。我们对身体成分、心脏代谢风险因素、生化变量和体能进行了评估。对血清中 55 种细胞因子的浓度进行了量化。我们还计算了胰岛素抵抗稳态模型评估（HOMA-IR）以及 AST/ALT 和 TG/HDL 比率。HOMA-IR大于2.5的青少年即为IR青少年。研究中共有 91 名青少年患有 IR（66% 为女孩）。在IS组中，在控制了混杂因素后，较高的IL-15水平分别与较高的丙氨酸氨基转移酶水平和较低的谷草转氨酶/谷丙转氨酶比率显著相关（PsConclusions：这些数据为了解青少年红外热的发病机制提供了新的视角，为预防红外热提供了新的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.