Life years lost by childhood cancer treatment and health related late effects among childhood cancer survivors

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2024-11-07 DOI:10.1016/j.canep.2024.102692

Thibaud Charrier , Nadia Haddy , Brice Fresneau , Boris Schwartz , Neige Journy , Charlotte Demoor-Goldschmidt , Ibrahima Diallo , Isabelle Aerts , François Doz , Vincent Souchard , Giao Vu-Bezin , Anne Laprie , Sarah Lemler , Véronique Letort , Carole Rubino , Kaniav Kamary , Naïla Myriam Aba , Claire Ducos , Médéa Locquet , Florent de Vathaire , Aurélien Latouche

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引用次数: 0

Abstract

Background

Identifying risk factors contributing the most to mortality of childhood cancer survivors is essential to guide harm reduction efforts in childhood cancer treatments, and long-term follow-up of childhood cancer survivors.

Methods

We assessed Life Years Lost from childhood cancer treatments and their health-related late effects among the French Childhood Cancer Survivors Study, a cohort of 7670 5-year childhood cancer survivors. Using a landmark strategy, we also assessed time-varying effects of risk factors, and how the multi-morbidity affects life years lost.

Results

We found subsequent malignant neoplasm (9.0 years [95 %CI: 4.3–13.7]), severe cardiac disease (8.0 years [95 %CI: 1.2–14.9]), and the use of radiotherapy (6.0 years [95 %CI: 4.7–7.3]) to be the highest contributors to Life Years Lost among childhood cancer survivors. We found no interaction impact on life years lost between health related late effects considered.

Conclusions

Those findings suggest that radiotherapy is the root cause of early mortality among childhood cancer survivors. Moreover patients experiencing a subsequent malignant neoplasm or a cardiac disease should be monitored closely after the event, as comorbidity is common and causes premature deaths.

查看原文本刊更多论文

儿童癌症治疗损失的寿命年数以及儿童癌症幸存者中与健康相关的晚期影响。

背景：确定导致儿童癌症幸存者死亡的最主要风险因素对于指导儿童癌症治疗中的减害工作以及儿童癌症幸存者的长期随访至关重要：我们评估了 "法国儿童癌症幸存者研究"（French Childhood Cancer Survivors Study）中儿童癌症治疗损失的生命年数及其对健康的后期影响。我们还采用地标策略评估了风险因素的时变效应，以及多种疾病如何影响寿命损失：我们发现，恶性肿瘤（9.0 年 [95 %CI：4.3-13.7]）、严重心脏病（8.0 年 [95 %CI：1.2-14.9]）和放疗（6.0 年 [95 %CI：4.7-7.3]）是导致儿童癌症幸存者寿命损失最多的因素。我们发现，与健康相关的晚期效应对寿命损失年数没有交互影响：这些研究结果表明，放疗是导致儿童癌症幸存者早期死亡的根本原因。此外，由于合并症很常见并会导致过早死亡，因此应密切监测继发恶性肿瘤或心脏病的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.