Gastrointestinal tract cleavage of α-synuclein by asparaginyl endopeptidase leads to Parkinson's disease.

IF 14.7 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2024-11-06 DOI:10.1016/j.neuron.2024.10.015

Longfei Li, Valina L Dawson, Ted M Dawson

引用次数: 0

Abstract

Pathologic α-synuclein (α-syn) aggregates from the gastrointestinal (GI) tract may contribute to Parkinson's disease (PD). Xiang et al.¹ report in Neuron that enteric nervous system-specific expression of asparaginyl endopeptidase (AEP)-truncated α-syn and tau spreads to the brain, synergistically causing PD-related neurodegeneration and neurobehavioral deficits.

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天冬酰胺酰内肽酶通过胃肠道裂解α-突触核蛋白导致帕金森病。

来自胃肠道的病理性α-突触核蛋白（α-syn）聚集可能是帕金森病（PD）的诱因。Xiang等人1在《神经元》（Neuron）杂志上报告说，肠道神经系统特异性表达的天冬酰胺酰内肽酶（AEP）截短的α-syn和tau会扩散到大脑，协同导致帕金森病相关的神经变性和神经行为障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.