A forgotten chapter in the history of immunotherapy: cancer therapy with Blastomyces extracts.

IF 3.2 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Internal and Emergency Medicine Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI:10.1007/s11739-024-03782-6

Francesco M Galassi, Domenico Ribatti

引用次数: 0

Abstract

This article recapitulates the discoveries and anti-tumoural therapeutical proposals by Francesco Sanfelice, who in 1931 published an essay entitled The Treatment of Cancer and Sarcoma with Cancrocidin (paraneoforming Blastomycetes). Sanfelice's discoveries are contextualised with subsequent scientific discoveries, especially with those by L. Scott McDaniel and G. Cozad, who evaluated the functionality of murine peritoneal macrophages previously sensitised precisely with Blastomyces dermatitidis antigen extracts. Finally, recent research on the topic of intratumoural microbiota is mentioned showing how Sanfelice's ideas, albeit partly outdated, can still inspire current biomolecular research.

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免疫疗法史上被遗忘的篇章：用高疫霉菌提取物治疗癌症。

这篇文章回顾了弗朗切斯科-桑费利斯（Francesco Sanfelice）的发现和抗肿瘤治疗建议，他于 1931 年发表了一篇题为《用癌细胞素（副噬菌体）治疗癌症和肉瘤》（The Treatment of Cancer and Sarcoma with Cancrocidin）的文章。Sanfelice 的发现与随后的科学发现相结合，特别是与 L. Scott McDaniel 和 G. Cozad 的发现相结合。最后，我们还提到了最近关于肿瘤内微生物群的研究，这表明桑费利斯的观点尽管部分已经过时，但仍能启发当前的生物分子研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal and Emergency Medicine 医学-医学：内科

CiteScore

7.20

自引率

4.30%

发文量

258

审稿时长

6-12 weeks

期刊介绍： Internal and Emergency Medicine (IEM) is an independent, international, English-language, peer-reviewed journal designed for internists and emergency physicians. IEM publishes a variety of manuscript types including Original investigations, Review articles, Letters to the Editor, Editorials and Commentaries. Occasionally IEM accepts unsolicited Reviews, Commentaries or Editorials. The journal is divided into three sections, i.e., Internal Medicine, Emergency Medicine and Clinical Evidence and Health Technology Assessment, with three separate editorial boards. In the Internal Medicine section, invited Case records and Physical examinations, devoted to underlining the role of a clinical approach in selected clinical cases, are also published. The Emergency Medicine section will include a Morbidity and Mortality Report and an Airway Forum concerning the management of difficult airway problems. As far as Critical Care is becoming an integral part of Emergency Medicine, a new sub-section will report the literature that concerns the interface not only for the care of the critical patient in the Emergency Department, but also in the Intensive Care Unit. Finally, in the Clinical Evidence and Health Technology Assessment section brief discussions of topics of evidence-based medicine (Cochrane’s corner) and Research updates are published. IEM encourages letters of rebuttal and criticism of published articles. Topics of interest include all subjects that relate to the science and practice of Internal and Emergency Medicine.