Recent advances in the total synthesis of alkaloids using chiral secondary amine organocatalysts.

Abstract

Since the early 21st century, organocatalytic reactions have undergone significant advancements. Notably, numerous asymmetric reactions utilizing chiral secondary amine catalysts have been developed and applied in the total synthesis of natural products. In this review, we provide an overview of alkaloid syntheses reported since 2017, categorized by scaffold, with a focus on key steps involving asymmetric reactions catalyzed by secondary amine organocatalysts.