Getting the Numbers Right in Medicinal Chemistry.

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2024-11-08 DOI:10.1002/cmdc.202400620

Christian Ducho

引用次数: 0

Abstract

Medicinal Chemistry is a quantitative scientific discipline. Hence, it is of utmost importance that scientists working in this field pay rigorous attention to the correct representation of their quantitative data. However, browsing the Medicinal Chemistry literature, it becomes obvious that this is very often not the case. In particular, results from biological assays are too frequently reported with unreasonable numbers of significant figures. In this Perspective, it is argued that this is poor practice that sheds an unfortunate light on the discipline of Medicinal Chemistry and that therefore, more rigorous policies regarding the presentation of quantitative data in Medicinal Chemistry publications should be considered.

查看原文本刊更多论文

药物化学中的正确数字。

药物化学是一门定量科学学科。因此，从事该领域研究的科学家必须严格关注定量数据的正确表达。然而，浏览药物化学文献就会发现，情况往往并非如此。特别是，在报告生物检测结果时，经常使用不合理的有效数字。本视角认为，这是一种不良做法，给药物化学学科蒙上了不幸的阴影，因此应考虑在药物化学出版物中采用更严格的定量数据表述政策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.