Palladium-catalyzed difluoroalkylative carbonylation of unactivated alkenes toward γ-Lactams

IF 6.5 1区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Catalysis Pub Date : 2024-11-13 DOI:10.1016/j.jcat.2024.115839

Xin Qi , Yuanrui Wang , Xiao-Feng Wu

引用次数: 0

Abstract

γ-Lactams are important core structure found in various natural and biologically active compounds. And the introducing of difluoromethylene group into a molecule can change its physical, chemical, and biological properties. As carbonylation chemistry represent a powerful and efficient method for the synthesis of carbonylated compounds, we report here an efficient procedure for the construction of difluoroalkylative γ-lactams via palladium-catalyzed carbonylative cyclization of alkenes. The desired γ-lactams were produced in moderate to good yields under relatively mild conditions.

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钯催化未活化烯烃的二氟烷基化羰基化反应生成 γ-内酰胺

γ-内酰胺是存在于各种天然和生物活性化合物中的重要核心结构。在分子中引入二氟亚基可以改变其物理、化学和生物性质。羰基化化学是合成羰基化化合物的一种强大而有效的方法，因此我们在此报告一种通过钯催化烯烃的羰基化环化来构建二氟烷基γ-内酰胺的有效方法。在相对温和的条件下，所需的γ-内酰胺以中等到良好的收率生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Catalysis 工程技术-工程：化工

CiteScore

12.30

自引率

5.50%

发文量

447

审稿时长

31 days

期刊介绍： The Journal of Catalysis publishes scholarly articles on both heterogeneous and homogeneous catalysis, covering a wide range of chemical transformations. These include various types of catalysis, such as those mediated by photons, plasmons, and electrons. The focus of the studies is to understand the relationship between catalytic function and the underlying chemical properties of surfaces and metal complexes. The articles in the journal offer innovative concepts and explore the synthesis and kinetics of inorganic solids and homogeneous complexes. Furthermore, they discuss spectroscopic techniques for characterizing catalysts, investigate the interaction of probes and reacting species with catalysts, and employ theoretical methods. The research presented in the journal should have direct relevance to the field of catalytic processes, addressing either fundamental aspects or applications of catalysis.