Experimental Evaluation of a New Perfusion Machine Using Normothermic Cycles on Explanted Livers

IF 2.7 Q3 ENGINEERING, BIOMEDICAL

IEEE Open Journal of Engineering in Medicine and Biology Pub Date : 2024-10-11 DOI:10.1109/OJEMB.2024.3478791

Eleonora Barcali;Lorenzo Maggi;Rebecca Panconesi;Fabio Staderini;Leonardo Bocchi;Cosimo Nardi;Nadia Navari;Adriano Peris;Matteo Risaliti;Mauricio F. Carvalho;Fabio Marra;Philipp Dutkowski;Gian Luca Grazi;Andrea Schlegel;Filippo Bigi;Mattia Dimitri;Andrea Corvi

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引用次数: 0

Abstract

Goal: Organ perfusion is a vast subject with several techniques, the most common being Hypothermic Machine Perfusion (HMP) and Normothermic Machine Perfusion (NMP). In this paper, a new machine developed at the Biolab of the University of Florence has been tested to validate its capability to perform a well-controlled Oxygenated Rewarming (COR) phase and maintain stability during the NMP phase. Methods: The tests (n = 5) were conducted on fresh porcine livers and evaluated according to liver perfusion standards. The developed machine is based on a previous version, with an integrated control and sensor system and a complete mechanical and electronic redesign. Results: The results demonstrate the excellent usability of the machine and its ability to effectively maintain the organs in good condition. The new system performed well, and the measures made on the livers were satisfactory for good preservation of the organ. Conclusion: This study showed the effectiveness of the developed machine. Future development of the system will include a more sophisticated control system to ensure the correct parameters for perfusion.

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对使用常温循环的新型灌注机进行实验评估

目标：器官灌注是一个庞大的课题，有多种技术，最常见的是低温机器灌注（HMP）和常温机器灌注（NMP）。本文对佛罗伦萨大学生物实验室开发的新型机器进行了测试，以验证其是否有能力执行良好的充氧复温（COR）阶段，并在 NMP 阶段保持稳定。测试方法测试（n = 5）在新鲜猪肝上进行，并根据肝脏灌注标准进行评估。所开发的机器基于之前的版本，集成了控制和传感器系统，并进行了全面的机械和电子重新设计。结果结果表明，该机器具有出色的可用性，能够有效保持器官的良好状态。新系统性能良好，对肝脏采取的措施也令人满意，从而很好地保存了器官。结论这项研究显示了所开发机器的有效性。该系统的未来发展将包括一个更复杂的控制系统，以确保灌注参数的正确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Open Journal of Engineering in Medicine and Biology ENGINEERING, BIOMEDICAL-

CiteScore

9.50

自引率

3.40%

发文量

审稿时长

10 weeks

期刊介绍： The IEEE Open Journal of Engineering in Medicine and Biology (IEEE OJEMB) is dedicated to serving the community of innovators in medicine, technology, and the sciences, with the core goal of advancing the highest-quality interdisciplinary research between these disciplines. The journal firmly believes that the future of medicine depends on close collaboration between biology and technology, and that fostering interaction between these fields is an important way to advance key discoveries that can improve clinical care.IEEE OJEMB is a gold open access journal in which the authors retain the copyright to their papers and readers have free access to the full text and PDFs on the IEEE Xplore® Digital Library. However, authors are required to pay an article processing fee at the time their paper is accepted for publication, using to cover the cost of publication.