Lipid droplet messengers

IF 17.3 1区 生物学 Q1 CELL BIOLOGY
Melina Casadio
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引用次数: 0
脂滴信使
第 2 组先天性淋巴细胞(ILC2s)在哮喘的气道炎症中发挥着重要作用。ILC2s 被激活后会形成脂滴(LDs)。Rao 等人的研究表明,在气道炎症模型中,ILC2s 中的 LD 积累会促进 HMGB1(一种损伤相关分子模式分子)的分泌和中性粒细胞趋化。研究人员通过鼻内 IL-33 在对照组小鼠或缺乏 T 细胞和 B 细胞(Rag1-/-)或缺乏 T 细胞、B 细胞和 ILCs(Rag2-/-Il2rg-/-)的小鼠中引发气道炎症。他们利用IL2Cs的收养性转移表明,ILC2促进了中性粒细胞向支气管肺泡灌洗液的浸润,ILC2分泌组分析、跨孔实验、抑制剂和体内研究表明,这是ILC2衍生的HMGB1所致。
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来源期刊
Nature Cell Biology
Nature Cell Biology 生物-细胞生物学
CiteScore
28.40
自引率
0.90%
发文量
219
审稿时长
3 months
期刊介绍: Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology
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