Electron-Donor-Mediated Divergent Transformation of Br–RF via EDA Complex for the Synthesis of Fluorine-Containing Oxindoles and Amides

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-11-11 DOI:10.1021/acs.orglett.4c03830

Shu-Peng Zhang, Jin-Xin Lan, Mei-Ling Yang, Jing-Yi Cao, Yicheng Zhang, Wen-Chao Yang

引用次数: 0

Abstract

We have developed an unprecedented electron-donor-controlled divergent reaction between N-alkylsulfonylated acrylamides and Br–R_F, facilitated by an electron donor–acceptor (EDA) complex, for the synthesis of fluorine-containing oxindoles and amides. Key to this divergent transformation is the EDA complex generation by altering electron donors. This approach has several advantages, such as broad substrate scope, being metal-catalyst- and photocatalyst-free, and having good functional group tolerance.

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电子供体介导的 Br-RF 通过 EDA 复合物进行发散转化以合成含氟吲哚和酰胺

我们在电子供体-受体（EDA）复合物的促进下，在 N-烷基磺酰化丙烯酰胺和 Br-RF 之间开发了一种前所未有的电子供体控制的发散反应，用于合成含氟吲哚和酰胺。这种分歧转化的关键是通过改变电子供体生成 EDA 复合物。这种方法有几个优点，如底物范围广、不含金属催化剂和光催化剂，以及对官能团有良好的耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.