Front Cover: Methanol-Mediated One-Pot Transformation of Benzonitriles to Five and Six-Membered Heterocycles: Synthesis and Mechanistic Approach (Eur. J. Org. Chem. 41/2024)

Abstract

The Front Cover shows methanolic media as a vehicle for a green, one-pot and metal-free synthetic approach to 5- and 6-membered N-heterocycle clusters, starting with benzonitriles and different available diamines and amino alcohols. The dual role of methanol as solvent and as mediated agent is supported by mechanistic and theoretical studies. More information can be found in the Research Article by I. N. Lykakis and co-workers (DOI: 10.1002/ejoc.202400601).