Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-11-07 DOI:10.1002/alz.14296

Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler Ward, Susan M. Landau, Suzanne L. Baker, Theresa M. Harrison, William J. Jagust

引用次数: 0

Abstract

Factors responsible for the deposition of pathological tau in the brain are incompletely understood. This study links macroscale tau deposition in the human brain to cerebrospinal fluid (CSF) flow dynamics using resting-state functional magnetic resonance imaging (rsfMRI).

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全脑活动及其与脑脊液流动的耦合与 tau 病理学有关

病理tau在大脑中沉积的因素尚不完全清楚。这项研究利用静息态功能磁共振成像（rsfMRI）将人脑中的大尺度tau沉积与脑脊液（CSF）流动动力学联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.