Homobarrelenones: Versatile Building Blocks for the Construction of Novel and Structurally Diverse Scaffolds

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2024-11-08 DOI:10.1002/ejoc.202400887

Valeria Lucero, Hugo do Carmo, Gabriel Fernández, Mauricio Cabrera, Macarena Eugui, Guillermo Moyna

引用次数: 0

Abstract

We describe the derivatization of tropolone‑based homobarrelenones through simple transformations, including catalytic hydrogenations, basic solvolysis, and hydride reductions. Despite being structurally complex and highly functionalized, the novel compounds had no significant cytotoxicity in sperm motility assays, underscoring the importance of Michael acceptor moieties in the biological activity of this class of compounds.

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同巴利酮：构建结构多样的新型支架的多功能构件

我们介绍了通过催化氢化、碱性溶解和氢化物还原等简单的转化过程对基于三苯酮的均苯四甲酰烯酮进行衍生化的过程。尽管这些新型化合物结构复杂、官能度高，但在精子活力实验中却没有明显的细胞毒性，这突出了迈克尔受体分子在这类化合物生物活性中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.