Analysis suggests risk of suicidal ideation associated with semaglutide

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Abstract

An analysis of a global database documenting adverse drug reactions has detected a disproportional occurrence of suicidal ideation associated with use of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide. This association was not present with use of the GLP-1 receptor agonist liraglutide or with other medications used to treat type 2 diabetes or obesity. Study results were published online Aug. 20, 2024 in JAMA Network Open.

分析表明,自杀意念风险与塞马鲁肽有关
一项对记录药物不良反应的全球数据库的分析发现,与使用胰高血糖素样肽-1(GLP-1)受体激动剂塞马鲁肽有关的自杀意念发生率过高。而使用GLP-1受体激动剂利拉鲁肽或其他治疗2型糖尿病或肥胖症的药物则不存在这种关联。研究结果于2024年8月20日在线发表在《美国医学会杂志网络版》(JAMA Network Open)上。
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