One-Pot Multicomponent Synthesis of Substituted 1,6-Naphthyridine Derivatives Employing 4-Aminocumarin

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2024-09-30 DOI:10.1002/aoc.7718

Elham Ezzatzadeh, Mahsa Hojjati, Azadeh Parhami, Zinatossadat Hossaini

引用次数: 0

Abstract

This study synthesized 1,6-naphthyridine as a novel class of fused heterocyclic compounds with high efficiency using a multicomponent reaction. The reaction involved benzaldehyde or its derivatives, 2 mol of malononitrile, and 4-aminocumarin in an aqueous solution at room temperature in the presence of SiO₂/Fe₃O₄@MWCNTs as a recyclable catalyst. This study examines the antioxidant properties of 1,6-naphthyridine in addition to the other research undertaken in this work. The production process of 1,6-naphthyridine demonstrated several advantageous features, including rapid reactions, high yields of the final product, and straightforward separation of the catalyst and product from the reaction mixture.

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利用 4-Aminocumarin 单锅多组分合成被取代的 1,6-萘啶衍生物

本研究利用多组分反应高效合成了 1,6-萘啶这一类新型融合杂环化合物。该反应涉及室温下水溶液中的苯甲醛或其衍生物、2 mol 丙二腈和 4-aminocumarin，以 SiO2/Fe3O4@MWCNTs 为可循环催化剂。本研究除了探讨 1,6-萘啶的抗氧化特性外，还对其进行了其他研究。1,6-萘啶的生产工艺显示出若干优势特点，包括反应快速、最终产品收率高、催化剂和产品可从反应混合物中直接分离。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.