Efficiency and Diversity in Chemical Synthesis: Exploring One-Pot Multicomponent Reactions

Abstract

This paper presents a broad overview of our research, which aims to develop new and effective synthetic approaches to structurally diverse heterocyclic scaffolds. Using multicomponent reactions (MCR), a wide variety of analogues from various families of heterocyclic compounds with many medicinal uses have been synthesized. Due to their affordability, eco-friendliness, and systematic synthesis in terms of reaction time, number of steps, yield, workup procedure, atom economy, and mild conditions, multicomponent reactions (MCRs) play a crucial role in achieving a greener approach in synthetic chemistry. MCRs offer a productive synthetic approach for a range of extremely complex compounds when paired with the one-pot process. The synthesis of highly functionalized molecules in a single pot to quickly generate libraries of biologically interesting compounds and find fresh leads as possible therapeutic agents is one of the distinctive features of MCRs. The current study covers the latest advancements and innovations of MCRs in the entire synthesis of nitrogen-, sulfur-, and oxygen-containing heterocyclic compounds.