Gold(III)-catalyzed regioselective synthesis of vinyl-substituted pyrazolo[1,4]-oxazepines via 7-exo-trig cyclization

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2024-11-02 DOI:10.1016/j.tet.2024.134340

Ravinder Guduru , Mathangi Sandeep , Komalla Sunil , N.S.V.M. Rao Mangina , Perla Bharath Kumar , Balasubramanian Sridhar , Galla V. Karunakar

引用次数: 0

Abstract

Vinyl-substituted pyrazo[1,4]-oxazepines were prepared through an intramolecular regioselective cyclization method under gold catalysis. This organic transformation achieved selective C–N bond formation via 7-exo-trig cyclization, resulting in vinyl-containg pyrazolo[1,4]-benzooxazepines and pyrazolo[1,4]-naphthoxazepines in one-pot with moderate to very good yields.

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金(III)催化的乙烯基取代的吡唑并[1,4]氮杂卓通过 7-exo-trig 环化的区域选择性合成

在金催化下，通过分子内区域选择性环化方法制备了乙烯基取代的吡唑并[1,4]-氧氮杂卓。这种有机转化通过 7-exo-trig 环化实现了选择性 C-N 键的形成，从而以中等至非常好的收率，在一锅中制备出乙烯基构象的吡唑并[1,4]-苯并氧氮杂卓和吡唑并[1,4]-萘并氧氮杂卓。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.