[Prognostic impact of early initiation of chemotherapy after brain biopsy in primary central nervous system lymphoma].

Yasutaka Masuda, Ken Morita, Mineo Kurokawa
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引用次数: 0

Abstract

Primary central nervous system lymphoma (PCNSL) is a B-cell lymphoma confined to the CNS. In general, early initiation of treatment after diagnosis is considered to be associated with improved prognosis in patients with malignancy. However, the prognostic impact of the time from diagnostic brain biopsy to initiation of treatment in patients with PCNSL remains unclear. In this study, we retrospectively analyzed how time from diagnostic biopsy to rituximab-containing treatment correlated with prognosis in 19 patients with PCNSL. Patients with a better prognostic score defined by age and performance status at diagnosis tended to have a better prognosis if chemotherapy was initiated sooner after brain biopsy. In conclusion, earlier chemotherapy initiation after brain biopsy and definitive diagnosis should be considered in the treatment of PCNSL.

[原发性中枢神经系统淋巴瘤脑活检后尽早开始化疗的预后影响]。
原发性中枢神经系统淋巴瘤(PCNSL)是一种局限于中枢神经系统的B细胞淋巴瘤。一般认为,确诊后尽早开始治疗可改善恶性肿瘤患者的预后。然而,PCNSL 患者从诊断性脑活检到开始治疗的时间对预后的影响仍不明确。在这项研究中,我们回顾性分析了19名PCNSL患者从诊断性活检到接受含利妥昔单抗治疗的时间与预后的相关性。根据年龄和诊断时的表现状态对预后评分较高的患者进行脑活检后,如果较早开始化疗,预后往往较好。总之,在治疗 PCNSL 时应考虑在脑活检和明确诊断后尽早开始化疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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