Cellular response in three-dimensional spheroids and tissues exposed to real and simulated microgravity: a narrative review.

IF 4.4 1区物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES

npj Microgravity Pub Date : 2024-11-06 DOI:10.1038/s41526-024-00442-z

Daan W A van den Nieuwenhof, Lorenzo Moroni, Joshua Chou, Jochen Hinkelbein

引用次数: 0

Abstract

The rising aging population underscores the need for advances in tissue engineering and regenerative medicine. Alterations in cellular response in microgravity might be pivotal in unraveling the intricate cellular mechanisms governing tissue and organ regeneration. Microgravity could improve multicellular spheroid, tissue, and organ formation. This review summarizes microgravity-induced cellular alterations and highlights the potential of tissue engineering in microgravity for future breakthroughs in space travel, transplantation, drug testing, and personalized medicine.

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暴露于真实和模拟微重力的三维球体和组织中的细胞反应：叙述性综述。

老龄化人口的不断增加凸显了组织工程和再生医学进步的必要性。微重力下细胞反应的变化可能是揭示支配组织和器官再生的复杂细胞机制的关键。微重力可以改善多细胞球体、组织和器官的形成。这篇综述总结了微重力诱导的细胞变化，并强调了微重力下的组织工程在未来太空旅行、移植、药物测试和个性化医疗领域取得突破的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)

CiteScore

7.30

自引率

7.80%

发文量

审稿时长

9 weeks

期刊介绍： A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.