Diabetic Cardiomyopathy: What Clinicians Should Know.

IF 2.5 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

American Journal of Medicine Pub Date : 2024-11-04 DOI:10.1016/j.amjmed.2024.10.026

Hannah Smati, Yusuf Kamran Qadeer, Mario Rodriguez, Errol Moras, Gregg C Fonarow, Scott D Isaacs, Thomas H Marwick, Chayakrit Krittanawong

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引用次数: 0

Abstract

Diabetes has classically been associated with atherosclerotic cardiovascular disease. However, heart failure is now increasingly recognized as a prevalent and often first cardiovascular complication among patients with diabetes. Investigation of this epidemiological relationship has led to recognition of diabetic cardiomyopathy, or structural heart disease that develops in patients with diabetes and may lead to progressive heart failure independently of coronary artery disease or conventional cardiovascular risk factors such as hypertension. Despite increased awareness, clinical management of this common cardiovascular complication remains challenging, with no consensus on its diagnosis or treatment. The lack of specific therapy has been recognized as an unmet clinical need. In this review, we summarize current understanding of the hallmark metabolic and structural changes of diabetic cardiomyopathy, appraise current tools for diagnosis and staging among patients, and describe the emerging but still preclinical data on therapeutic options.

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糖尿病心肌病：临床医生须知。

糖尿病通常与动脉粥样硬化性心血管疾病相关。然而，现在越来越多的人认识到，心力衰竭是糖尿病患者普遍存在的一种心血管并发症，而且往往是第一种心血管并发症。通过对这一流行病学关系的研究，人们认识到糖尿病心肌病，即糖尿病患者发生结构性心脏病，并可能导致进行性心力衰竭，而与冠状动脉疾病或高血压等传统心血管风险因素无关。尽管人们对这一常见心血管并发症的认识有所提高，但其临床治疗仍然充满挑战，在诊断和治疗方面尚未达成共识。缺乏特异性疗法已被认为是尚未满足的临床需求。在这篇综述中，我们总结了目前对糖尿病心肌病标志性代谢和结构变化的认识，评估了目前对患者进行诊断和分期的工具，并描述了正在出现但仍处于临床前阶段的治疗方案数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Medicine 医学-医学：内科

CiteScore

6.30

自引率

3.40%

发文量

449

审稿时长

9 days

期刊介绍： The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine, both in academia and community-based practice. AJM is the official journal of the Alliance for Academic Internal Medicine, a prestigious group comprising internal medicine department chairs at more than 125 medical schools across the U.S. Each issue carries useful reviews as well as seminal articles of immediate interest to the practicing physician, including peer-reviewed, original scientific studies that have direct clinical significance and position papers on health care issues, medical education, and public policy.