Anti-IgE and food allergy.

IF 11.4 1区 医学 Q1 ALLERGY
Jennifer A Dantzer, Robert A Wood
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引用次数: 0

Abstract

Food allergy is a growing problem that can have a significant impact on both the individual, the family, and society. We are entering a new era of food allergy management with the recent US Food and Drug Administration approvals of 2 therapies for food allergy. IgE is now known to play a critical role in allergic diseases, including food allergy. Ant-IgE therapy has been under investigation for decades and is now approved for asthma, urticaria, nasal polyps, and most recently, IgE-mediated food allergy. Here, we evaluate what is known about the safety and efficacy of anti-IgE therapy as monotherapy and in combination with oral immunotherapy. In addition, we will highlight important practical considerations and key knowledge gaps.

抗 IgE 与食物过敏。
食物过敏是一个日益严重的问题,对个人、家庭和社会都会产生重大影响。最近,美国食品和药物管理局批准了两种治疗食物过敏的疗法,我们正在进入一个食物过敏管理的新时代。免疫球蛋白 E (IgE) 在过敏性疾病(包括食物过敏)中发挥着至关重要的作用。几十年来,抗 IgE 疗法一直在研究之中,目前已被批准用于治疗哮喘、荨麻疹、鼻息肉以及最近 IgE 介导的食物过敏。在此,我们将评估抗 IgE疗法作为单一疗法以及与口服免疫疗法联合使用的安全性和有效性。此外,我们还将强调重要的实际注意事项和关键的知识缺口。
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来源期刊
CiteScore
25.90
自引率
7.70%
发文量
1302
审稿时长
38 days
期刊介绍: The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.
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