Factors affected the ovarian reserve after laparoscopic cystectomy for ovarian endometriomas

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2024-10-28 DOI:10.1016/j.ejogrb.2024.10.045

Kit-Sum Mak , Yi-Ting Huang , Cindy Hsuan Weng , Kai-Yun Wu , Wei-Li Lin , Chin-Jung Wang

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引用次数: 0

Abstract

Objective

To identify related factors that affect the ovarian reserve after laparoscopic ovarian cystectomy in patients with endometriomas.

Study design

It was a retrospective cohort study performed in a tertiary-care university hospital. A total of 409 patients with endometriomas underwent laparoscopic ovarian cystectomy between June 2014 and November 2021.

Results

The demographic and operative data, including age, parity, body mass index, tumor size, operating time, and estimated blood loss were recorded. Serum anti-Mullerian hormone (AMH) levels were recorded preoperatively, as well as 10 days (immediately) and 6 months after the procedure respectively. The decrease of serum AMH level at 6 months after the surgery were 0.7 ± 1.6 ng/mL (22.5 ± 57.1 %) in the unilateral group and 1.5 ± 2.1 ng/mL (48.3 ± 65.6 %) in the bilateral group. The reduction in the serum AMH level at 10 days and 6 months after the operation were significant compared to the baseline level. The bilateral group has a significantly lower serum AMH level than that of the unilateral group in terms of 10 days and 6 months after operation (p < 0.001). Baseline serum AMH level < 2 ng/mL have shown less reduction in both 10 days group and 6 months group with odds ratio (OR) 0.36 (p = 0.01) and OR 0.264 (p < 0.001) respectively. Neither patient’s age nor tumor size contributed to the decline of ovarian reserve.

Conclusions

Bilaterality and pre-operative serum AMH level are the two key factors that affect ovarian reserve after laparoscopic cystectomy.

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卵巢子宫内膜瘤腹腔镜囊肿切除术后影响卵巢储备功能的因素。

研究目的确定影响子宫内膜异位症患者腹腔镜卵巢囊肿切除术后卵巢储备功能的相关因素：研究设计：这是一项在一家三级甲等大学医院进行的回顾性队列研究。2014年6月至2021年11月期间，共有409名子宫内膜异位症患者接受了腹腔镜卵巢囊肿切除术：记录了人口统计学和手术数据，包括年龄、胎次、体重指数、肿瘤大小、手术时间和估计失血量。分别记录了术前以及术后10天（即刻）和6个月的血清抗穆勒氏管激素（AMH）水平。术后6个月，单侧组血清AMH水平下降了0.7 ± 1.6纳克/毫升（22.5 ± 57.1%），双侧组下降了1.5 ± 2.1纳克/毫升（48.3 ± 65.6%）。与基线水平相比，术后 10 天和 6 个月的血清 AMH 水平均显著下降。双侧组在术后 10 天和 6 个月的血清 AMH 水平明显低于单侧组（P 结论：双侧组在术后 10 天和 6 个月的血清 AMH 水平明显低于单侧组：双侧和术前血清 AMH 水平是影响腹腔镜膀胱切除术后卵巢储备功能的两个关键因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.