HIV-1 remission following stem cell transplant without CCR5Δ32 mutation

IF 58.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Medicine Pub Date : 2024-11-06 DOI:10.1038/s41591-024-03365-0

引用次数: 0

Abstract

We report the first case of a person achieving sustained HIV-1 remission after transplantation with allogeneic hematopoietic stem cells that express wild-type CCR5 and thus are permissive to HIV-1 infection. The 53-year-old man received the transplant in 2018 to treat a rare myeloid sarcoma and has not experienced viral rebound since discontinuing antiretroviral therapy in November 2021.

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干细胞移植后艾滋病毒-1缓解，但无CCR5Δ32突变

我们报告了首例移植了表达野生型CCR5从而允许HIV-1感染的异体造血干细胞后实现HIV-1持续缓解的病例。这名 53 岁的男子于 2018 年接受了移植，以治疗罕见的骨髓肉瘤，自 2021 年 11 月停止抗逆转录病毒疗法以来，他的病毒没有反弹。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

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