Deep RNA sequencing of human dorsal root ganglion neurons reveals somatosensory mechanisms

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2024-11-06 DOI:10.1038/s41593-024-01795-0

引用次数: 0

Abstract

We used single-soma deep RNA sequencing to generate a high-resolution atlas of human somatosensory dorsal root ganglion neurons. This work revealed human-specific molecular features, pain-sensing neuron types, properties of sensory fibers, and potential therapeutic targets, which inform understanding of human somatosensory mechanisms and could facilitate improved success in translational research.

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人类背根神经节神经元的深度 RNA 测序揭示了躯体感觉机制

我们利用单瘤深度 RNA 测序生成了人类体感背根神经节神经元的高分辨率图谱。这项工作揭示了人类特有的分子特征、痛觉神经元类型、感觉纤维的特性以及潜在的治疗靶点，为了解人类体感机制提供了信息，有助于提高转化研究的成功率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.