Protein/polysaccharide based oral delivery system for precise targeting of polyphenols and carotenoids

IF 4.8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2024-10-18 DOI:10.1016/j.fbio.2024.105311

Wen Jiang, Shiyu Zhai, Li Zhu, Yanan Bai, Jianuo Li, Juxiu Li

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Abstract

The potential health benefits of polyphenols and carotenoids have attracted considerable interest. However, practical applications are hindered by several issues, including low stability, low bioavailability, and poor targeting. Polysaccharide/protein-based materials with high safety and biocompatibility are frequently employed in developing various delivery systems to tackle these challenges. Remarkably, targeted delivery systems are designed to deliver bioactive substances to specific targets after oral administration, increasing the concentration of the bioactive substance enriched at the target site and enhancing the biological effect. This review presents an overview of the design strategies and influencing factors for oral targeted delivery. The review particularly emphasizes the development and applications of oral targeted delivery for polyphenols and carotenoids at the system, cell, and subcellular compartment levels. Furthermore, this review delves into the intricacies of dual-targeted and multi-targeted cascade delivery strategies. The objective is to present novel insights into the delivery of polyphenols and carotenoids and offer methods and ideas for developing functional foods.

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基于蛋白质/多糖的口服给药系统，用于精确靶向多酚和类胡萝卜素

多酚和类胡萝卜素对健康的潜在益处引起了人们的极大兴趣。然而，稳定性低、生物利用率低和靶向性差等问题阻碍了它们的实际应用。为了应对这些挑战，人们在开发各种给药系统时经常采用安全性高、生物相容性好的多糖/蛋白质基材料。值得注意的是，靶向给药系统的设计目的是在口服后将生物活性物质输送到特定靶点，提高富集在靶点的生物活性物质的浓度，增强生物效应。本综述概述了口服靶向给药的设计策略和影响因素。综述特别强调了多酚类和类胡萝卜素口服靶向给药在系统、细胞和亚细胞区室水平上的开发和应用。此外，本综述还深入探讨了双靶向和多靶向级联给药策略的复杂性。目的是介绍多酚和类胡萝卜素递送的新见解，并提供开发功能食品的方法和思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.