Green synthesis, molecular docking and in vitro biological evaluation of novel hydrazones, pyrazoles, 1,2,4-triazoles and 1,3,4-oxadiazoles

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-10-24 DOI:10.1080/00397911.2024.2417362

Ahmed Younis , Asmaa F Kassem , Wael M Aboulthana , Ashraf A Sediek

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引用次数: 0

Abstract

Ultrasonic waves were used for synthesis of novel hydrazones, bishydrazones, pyrazoles, 1,2,4-triazole and 1,3,4-oxadiazole. The structural formulae of the synthesized compounds were elucidated in terms of elemental and spectroscopic analyses. All synthesized compounds were estimated by testing total antioxidant capacity, iron‐reducing power, the scavenging activity against ABTS and DPPH radicals in addition to testing anti‐diabetic, anti‐Alzheimer and anti‐arthritic activities. All compounds displayed good to potent bioactivity. Compounds 6, 10 exhibit the highest antioxidant and free radicals scavenging activities. Furthermore, compounds 6, 10 demonstrate the strongest inhibition of α‐amylase and α-glucosidase. Compound 12 exhibit strongest acetylcholinesterase inhibition among prepared compounds. However, compounds 18a,b, 19 show a significantly higher inhibition percentage for protein denaturation and proteinase. The most bioactive prepared compounds 6, 10 and 12 were investigated toward docking methodology against appropriate protein.

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新型肼、吡唑、1,2,4-三唑和 1,3,4-恶二唑的绿色合成、分子对接和体外生物学评价

利用超声波合成了新型肼、双肼、吡唑、1,2,4-三唑和 1,3,4-恶二唑。通过元素分析和光谱分析，阐明了合成化合物的结构式。通过测试总抗氧化能力、铁还原力、ABTS 和 DPPH 自由基清除活性以及抗糖尿病、抗老年痴呆和抗关节炎活性，对所有合成化合物进行了评估。所有化合物都显示出良好甚至强效的生物活性。化合物 6 和 10 的抗氧化和清除自由基活性最高。此外，化合物 6 和 10 对 α 淀粉酶和 α 葡萄糖苷酶的抑制作用最强。在制备的化合物中，化合物 12 对乙酰胆碱酯酶的抑制作用最强。然而，化合物 18a、b 和 19 对蛋白质变性和蛋白酶的抑制率明显更高。对生物活性最强的 6、10 和 12 号化合物进行了与相应蛋白质的对接研究。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.