1D, 3D supramolecular assemblies of a series of cyclometalated platinum(II) complexes with deep-red aggregation-induced phosphorescent emission and anion turn-on sensing via Pt-Pt interaction

IF 10.7 1区 生物学 Q1 BIOPHYSICS
Haiping Wu , Jiayan Yang , Pengchao Wang , Ruofei Sun, Ting Wang, Xiali Liao, Bo Yang, Chuanzhu Gao, Jing Yang
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Abstract

Controlling the size and morphology of supramolecular assemblies is still an enormous challenge for the development of novel functional materials. Herein, cyclometalated platinum(II) complexes were designed and used as effective theragnostic supramolecular nano agents. Benzoquinoline was used as the main C^N ligand, and the increased number of aromatic rings in the N^N ligand of Pt complexes could greatly improve lipophilicity and cytotoxicity towards cancer cells over normal cells. Moreover, the morphology of nanoparticles formed by self-assembly of Pta-d could change from one to three-dimensional (1-3D), which can form nanowires and nanospheres. Besides, complexes of Pta-c, the number of aromatic rings in the N^N ligand of which does not exceed 4, all exhibit significant aggregation-induced phosphorescent emission (AIPE) with 100 - 200-fold enhancement in red phosphoresce intensity recorded in the solvent of Pta-1 and Ptb. Pt-Pt interaction induced by coordination and electrostatic interaction between complex and anions, and a new deep red emission improvement was observed in aqueous solution of Pta and Ptb with the presence of ClO4, and two similar deep red emissions induced by two different interactions can be told by new emerging MMLCT absorption band. Ptd of dppz ligand exhibits the highest efficiency in inducing apoptosis of HeLa and its anticancer mechanism was studied. Our work aims to promote the fundamental comprehension of the self-assembly behavior of cyclometalated platinum complex with AIPE in vitro and living cells.
一系列环甲基化铂(II)配合物的一维、三维超分子组装,通过铂-铂相互作用实现深红色聚集诱导磷光发射和阴离子开启感应
控制超分子组装体的尺寸和形态仍然是开发新型功能材料的巨大挑战。本文设计了环甲基化铂(II)配合物,并将其用作有效的热敏超分子纳米制剂。铂配合物以苯并喹啉作为主要的 C^N 配体,N^N 配体中芳香环数量的增加可大大提高铂配合物的亲脂性和对癌细胞的细胞毒性。此外,Pta-d 自组装形成的纳米粒子形态可从一维变为三维(1-3D),可形成纳米线和纳米球。此外,N^N 配体中芳香环数目不超过 4 个的 Pta-c 复合物都表现出显著的聚集诱导磷光发射(AIPE),在 Pta-1 和 Ptb 溶剂中记录到的红色磷光强度增强了 100 - 200 倍。铂-铂相互作用是由配合物与阴离子之间的配位和静电作用引起的,在有 ClO4- 存在的 Pta 和 Ptb 的水溶液中观察到了新的深红色发射提高,从新出现的 MMLCT 吸收带可以看出两种不同的相互作用引起了两种类似的深红色发射。dppz 配体中的 Ptd 在诱导 HeLa 细胞凋亡方面表现出最高的效率,并对其抗癌机制进行了研究。我们的工作旨在促进从根本上理解环金属化铂配合物与 AIPE 在体外和活细胞中的自组装行为。
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来源期刊
Biosensors and Bioelectronics
Biosensors and Bioelectronics 工程技术-电化学
CiteScore
20.80
自引率
7.10%
发文量
1006
审稿时长
29 days
期刊介绍: Biosensors & Bioelectronics, along with its open access companion journal Biosensors & Bioelectronics: X, is the leading international publication in the field of biosensors and bioelectronics. It covers research, design, development, and application of biosensors, which are analytical devices incorporating biological materials with physicochemical transducers. These devices, including sensors, DNA chips, electronic noses, and lab-on-a-chip, produce digital signals proportional to specific analytes. Examples include immunosensors and enzyme-based biosensors, applied in various fields such as medicine, environmental monitoring, and food industry. The journal also focuses on molecular and supramolecular structures for enhancing device performance.
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