McArdle sign and neck flexion-induced change in central motor conduction in multiple sclerosis.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2024-11-06 DOI:10.1177/13524585241295868

E Matthew Hoffman, Lucille Brown, Evan Jolliffe, Elia Sechi, William S Harmsen, Nathan D Schilaty, Brian G Weinshenker

引用次数: 0

Abstract

Background: Rapidly reversible weakness with neck flexion (McArdle sign) is common in patients with multiple sclerosis (MS). The pathophysiology is unknown.

Objective: To evaluate changes in central motor conduction time (CMCT) in patients with and without McArdle sign.

Methods: We measured McArdle sign with a torque cell and CMCT with neck flexed and extended in patients with MS, other causes of myelopathy, and healthy controls.

Results: CMCT was prolonged with neck flexion disproportionately in those with MS-associated myelopathy (MSAM) with prominent McArdle sign compared to MS patients with lesser degrees of McArdle sign, and to controls.

Conclusion: McArdle sign may result from stretch-induced slowing of conduction due to demyelination.

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多发性硬化症患者的麦卡德尔征和颈部屈曲引起的中枢运动传导变化。

背景：多发性硬化症（MS）患者常见颈部屈曲无力（McArdle征），且可快速逆转。其病理生理学尚不清楚：评估伴有和不伴有麦卡德尔征的患者中枢运动传导时间（CMCT）的变化：方法：我们用力矩电池测量了多发性硬化症患者、其他原因引起的脊髓病患者和健康对照组的麦卡德尔征以及颈部屈曲和伸展时的 CMCT：结果：与麦卡德尔征程度较轻的多发性硬化症患者和对照组相比，麦卡德尔征明显的多发性硬化症相关性脊髓病（MSAM）患者在颈部屈曲时CMCT延长得不成比例：结论：McArdle征可能是由于脱髓鞘导致的拉伸引起的传导减慢所致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585