GABA in early brain development: A dual role review

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2024-11-06 DOI:10.1002/jdn.10387

Xiaoyu Ji, Shuzhen Liu, Shiyong Li, Xing Li, Ailin Luo, Xue Zhang, Yilin Zhao

引用次数: 0

Abstract

This comprehensive review examines the multifaceted roles of gamma-aminobutyric acid (GABA) in early brain development. GABA, traditionally recognized for its inhibitory functions in the mature brain, also exhibits excitatory effects during early neural development. This article explores the mechanisms behind GABA's dual roles, detailing its impact on the properties of the immature brain, the mechanisms of GABA-mediated excitation, the role of GABA-mediated presynaptic inhibition, the trophic actions of GABA during early development, GABA regulation of neurite growth and GABA-mediated cell differentiation in the immature brain. Emphasizing recent research findings, the review highlights the significance of GABAergic signalling in shaping the developing brain and its potential implications for understanding neurodevelopmental disorders.

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GABA 在早期大脑发育中的作用：双重作用综述。

这篇综述探讨了γ-氨基丁酸（GABA）在大脑早期发育中的多方面作用。传统上认为 GABA 在成熟大脑中具有抑制作用，但它在早期神经发育过程中也具有兴奋作用。本文探讨了GABA双重作用背后的机制，详细介绍了GABA对未成熟脑特性的影响、GABA介导的兴奋机制、GABA介导的突触前抑制作用、GABA在早期发育过程中的营养作用、GABA对神经元生长的调控以及GABA介导的未成熟脑细胞分化。这篇综述强调了最新的研究成果，突出了GABA能信号在塑造大脑发育过程中的重要作用及其对理解神经发育障碍的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.