Environmental realism in molecular ecotoxicology: key considerations to transition experimental data to ecologically relevant scenarios.

Abstract

Molecular ecotoxicology facilitates the mechanistic understanding of chemical-organism interactions and the establishment of frameworks to link molecular events to adverse outcomes. However, the foundation of this sub-discipline must remain focused on the necessity to generate insight at levels of biological organization beyond the individual, namely the population, community, and ecosystem levels, and to strive towards ecological relevance. As planet Earth continues to experience unprecedented levels of chemical pollution, causing significant impact to the integrity and functionality of ecosystems, research efforts in molecular ecotoxicology must prioritize experimentation that quantitatively incorporates the influence of non-chemical stressors to enhance the predictability of chemical-driven effects at the population level and beyond. Here, perspectives on the challenge to transition experimental data to environmentally relevant scenarios are offered in an attempt to highlight the critical role of molecular ecotoxicology in protecting and supporting ecosystems threatened by chemical pollution.