Aline Martins de Oliveira, Rafael Matias Silva, Alexsandra Dias da Silva, Tiago Almeida Silva
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引用次数: 0
Abstract
An overview of the latest advances in the design of electrochemical sensor architectures dedicated to the determination of drugs from the statin class is presented in this review. Statins are drugs widely consumed for cholesterol control, and their determination in different matrices through the application of electroanalysis is growing considering advantages such as operational simplicity, lower cost and ease of sample preparation. Within the context of statins, electrochemical sensor architectures can be subdivided into conventional/classical electrodes such as glassy carbon electrodes, carbon paste electrodes, pencil graphite electrodes, boron-doped diamond electrodes and metallic electrodes, and more modern electrode systems, including the screen-printed electrodes and 3D-printed electrodes. Thus, different aspects related to the preparation of these electrochemical sensors and analytical performance are presented, also reflecting advances in terms of designs of new architectures and possible improvements not previously reviewed. Analyzed samples, advantages and disadvantages of different implemented sensor's modification strategies and perspectives for the electroanalysis of statins are also included throughout the work.
本综述概述了用于测定他汀类药物的电化学传感器结构设计的最新进展。他汀类药物是广泛用于控制胆固醇的药物,考虑到其操作简单、成本较低和易于样品制备等优点,通过应用电分析法在不同基质中测定他汀类药物的方法越来越多。就他汀类药物而言,电化学传感器结构可细分为传统/经典电极(如玻璃碳电极、碳浆电极、铅笔石墨电极、掺硼金刚石电极和金属电极)和更现代的电极系统(包括丝网印刷电极和 3D 印刷电极)。因此,本文介绍了与这些电化学传感器的制备和分析性能有关的各个方面,同时也反映了新结构设计方面的进展以及以前未曾介绍过的可能的改进。分析的样品、不同传感器改进策略的优缺点以及他汀类药物电分析的前景也贯穿了整个研究工作。
期刊介绍:
Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area.
This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following:
· chemical analysis;
· instrumentation;
· chemometrics;
· analytical biochemistry;
· medicinal analysis;
· forensics;
· environmental sciences;
· applied physics;
· and material science.