Enlarged choroid plexus related to atrophy of hippocampal subfield volumes and glymphatic dysfunction in benzodiazepine use disorder.

IF 3.1 3区医学 Q2 PHARMACOLOGY & PHARMACY

British journal of clinical pharmacology Pub Date : 2024-11-05 DOI:10.1111/bcp.16328

Yang Zhou, Meizhi Yi, Xun Li, Tianyao Wang, Yihong Jiang, Luokai Zhang, Jun Hu, Huiting Wu, Wei Zou, Jun Liu, Hong Zhou

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引用次数: 0

Abstract

Aims: The aim of this study was to explore the relationship of choroid plexus (CP) volume with hippocampal subregion volume and glymphatic system in patients with benzodiazepine use disorders (BUD).

Methods: Eighty-four participants were recruited including 23 patients with BUD, 29 patients with chronic insomnia (CI) and 32 healthy controls (HC). The morphological alterations in CP, hippocampal subfield volumes and diffusion tensor image analysis along the perivascular space (DTI-ALPS) index were compared between the three groups and the relationships between CP volume and hippocampal subfield volumes and the glymphatic system were further investigated.

Results: Compared with the HC individuals, the CP volumes augmented and hippocampal subfield volumes reduced in patients with BUD (P < .05) but not in patients with CI (P > .05). In patients with BUD, there were extensive relationships between augmented CP volume and decreased hippocampal subfield volumes (P < .05, r = -0.421--0.513). CP volume was negatively related with the DTI-ALPS index (r = -0.582, P = .004) within the BUD group. In patients with BUD, the volume of bilateral cornu ammonis (CA)1 body, molecular layer (ML) body, hippocampal tail, left CA1 head volumes, right dentate gyrus body volumes, and right CA4 body volumes were positively related with the Montreal Cognitive Assessment scores (P < .05, r = 0.422-0.683). Right CA1 and ML body volumes positively related with the Mini-Mental State Examination scores (P < .05, r = 0.503-0.575).

Conclusions: The enlarged CP related to atrophy of hippocampal subfield volumes and the glymphatic system dysfunction were shown in BUD patients.

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脉络丛扩大与苯并二氮杂卓使用障碍患者海马亚区体积萎缩和脑功能障碍有关。

目的：本研究旨在探讨苯并二氮杂卓使用障碍（BUD）患者脉络丛（CP）体积与海马亚区体积和甘油系统的关系：招募了84名参与者，包括23名苯二氮卓类药物使用障碍（BUD）患者、29名慢性失眠（CI）患者和32名健康对照组（HC）。比较了三组患者的CP形态学改变、海马子野体积和沿血管周围空间的弥散张量图像分析（DTI-ALPS）指数，并进一步研究了CP体积、海马子野体积与甘油系统之间的关系：与正常人相比，BUD 患者的 CP 体积增大，海马亚场体积缩小（P .05）。在 BUD 患者中，CP 体积增大与海马子野体积缩小之间存在广泛的关系（P 结论：CP 体积增大与海马子野体积缩小之间存在广泛的关系：在 BUD 患者中，CP 的增大与海马亚场体积的萎缩和脑 glymphatic 系统功能障碍有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British journal of clinical pharmacology 医学-药学

CiteScore

6.30

自引率

8.80%

发文量

419

审稿时长

1 months

期刊介绍： Published on behalf of the British Pharmacological Society, the British Journal of Clinical Pharmacology features papers and reports on all aspects of drug action in humans: review articles, mini review articles, original papers, commentaries, editorials and letters. The Journal enjoys a wide readership, bridging the gap between the medical profession, clinical research and the pharmaceutical industry. It also publishes research on new methods, new drugs and new approaches to treatment. The Journal is recognised as one of the leading publications in its field. It is online only, publishes open access research through its OnlineOpen programme and is published monthly.