Prevalence of vaginal and cervical HPV infection among 35-year age cohort ever-married women in Kalutara district of Sri Lanka and the validity of vaginal HPV/DNA specimen as a cervical cancer screening tool: a cross-sectional study.

IF 3.4 3区 医学 Q2 INFECTIOUS DISEASES
Kcm Perera, K N Mapitigama, Htcs Abeysena
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引用次数: 0

Abstract

Background: Cervical cancer is the 2nd most common female cancer among Sri Lankan females and is almost associated with sexually transmitted cervicovaginal human papillomavirus (HPV) infection. The study objectives were to determine the prevalence of vaginal and cervical HPV infection among 35year old ever-married women and assess the validity of primary healthcare provider-collected vaginal HPV/DNA specimens as a cervical cancer screening tool to improve the coverage of the programme.

Method: A descriptive cross-sectional study was carried out from the 1st of September 2018 to the 31st of January 2019. Ever-married women 35 years of age in Kalutara district were the study population. Two women from each Public Health Midwife area (n = 413) were selected randomly from the relevant area eligible families register/s. HPV/DNA cervical specimen and vaginal specimen collection (n = 621) were carried out. Specimens were screened by the Cobas 4800 HPV/DNA automated Polymerase Chain Reaction (PCR) machine. Participants' profiles were recorded by the research assistants using an interviewer-administered questionnaire.

Results: The overall prevalence of vaginal and cervical HPV infection was 7.08% (95% CI; 5.2-9.4%) and 6.12% (95% CI; 4.26-8.3%) respectively. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), diagnostic accuracy, and the kappa coefficient of the vaginal HPV/DNA screening method vs. cervical HPV/DNA screening method were 100%, 98.9%, 86.4%, 100%, 99% and 0.92 respectively.

Conclusions: Vaginal HPV/DNA specimen screening method can be used as a cervical cancer screening tool due to its high validity. Pilots of the feasibility should be set up before the regional or national rollout of vaginal sampling strategies.

斯里兰卡卡卢塔拉地区 35 岁已婚妇女的阴道和宫颈 HPV 感染率以及阴道 HPV/DNA 标本作为宫颈癌筛查工具的有效性:一项横断面研究。
背景:宫颈癌是斯里兰卡女性第二大常见癌症,几乎与性传播的宫颈阴道人类乳头瘤病毒(HPV)感染有关。研究目标是确定 35 岁已婚妇女的阴道和宫颈 HPV 感染率,并评估初级保健提供者收集的阴道 HPV/DNA 标本作为宫颈癌筛查工具的有效性,以提高该计划的覆盖率:从 2018 年 9 月 1 日至 2019 年 1 月 31 日开展了一项描述性横断面研究。研究对象为卡卢塔拉地区 35 岁的已婚妇女。每个公共卫生助产士地区(n = 413)从相关地区合格家庭登记册中随机抽取两名妇女。进行了 HPV/DNA 宫颈标本和阴道标本采集(n = 621)。标本由 Cobas 4800 HPV/DNA 自动聚合酶链反应(PCR)机进行筛查。研究助理使用访谈者发放的调查问卷记录了参与者的情况:阴道和宫颈 HPV 感染的总体流行率分别为 7.08% (95% CI; 5.2-9.4%) 和 6.12% (95% CI; 4.26-8.3%)。阴道 HPV/DNA 筛查方法与宫颈 HPV/DNA 筛查方法的敏感性、特异性、阳性预测值 (PPV)、阴性预测值 (NPV)、诊断准确性和卡帕系数分别为 100%、98.9%、86.4%、100%、99% 和 0.92:阴道 HPV/DNA 标本筛查法的有效性较高,可用作宫颈癌筛查工具。在地区或全国范围内推广阴道采样策略之前,应先进行可行性试点。
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来源期刊
BMC Infectious Diseases
BMC Infectious Diseases 医学-传染病学
CiteScore
6.50
自引率
0.00%
发文量
860
审稿时长
3.3 months
期刊介绍: BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.
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