Photoinduced EDA Complex-Initiated Synthesis of Fluoroalkylated Isoquinolinonediones.

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2024-11-06 DOI:10.1002/chem.202403286

Lei Huang, Chaodong Wang, Zhi Chen, Qianxi Jin, Shengjie Song, Jiadi Zhou, Jianjun Li

引用次数: 0

Abstract

A visible-light-induced radical tandem difluoroalkylation/cyclization to construct CF₂-containing isoquinolinonedione skeletons with methacryloyl benzamides is developed. Broad substrate scopes are compatible with metal-, oxidant- and photocatalyst-free conditions under room temperature in good-to-excellent yields. Mechanistic analysis revealed that the transformation is initiated by photoinduced electron donor-acceptor (EDA) complexes formation.

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光诱导 EDA 复合物引发的氟烷基异喹啉酮类化合物的合成。

本研究开发了一种可见光诱导的自由基串联二氟烷基化/环化反应，以构建含有甲基丙烯酰基苯甲酰胺的含 CF2 的异喹啉酮骨架。在室温条件下，广泛的底物范围与无金属、无氧化剂和无光催化剂条件兼容，产率良好至极佳。机理分析表明，这种转化是由光诱导电子供体-受体（EDA）复合物的形成启动的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

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