Ancient and versatile CRISPR–Cas nuclease created with ancestral sequence reconstruction

IF 33.1 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nature biotechnology Pub Date : 2024-11-05 DOI:10.1038/s41587-024-02468-w

引用次数: 0

Abstract

Ancestral sequence reconstruction enables the identification and synthesis of ReChb, an ancient form of CRISPR–Cas12a with a highly versatile functionality. ReChb can target any nucleic acid, with minimal restrictions, making it a multipurpose tool for genome editing and genetic diagnostics.

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利用祖先序列重建技术创造出古老而多用途的 CRISPR-Cas 核酸酶

ReChb 是 CRISPR-Cas12a 的一种古老形式，具有多功能性。ReChb 可以靶向任何核酸，限制极少，是基因组编辑和基因诊断的多用途工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature biotechnology 工程技术-生物工程与应用微生物

CiteScore

63.00

自引率

1.70%

发文量

382

审稿时长

3 months

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