Mechanochemical cyclization of push-pull enamines with propargyl alcohols

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2024-10-29 DOI:10.1016/j.tet.2024.134339

Srinivasarao Yaragorla, Megavath Vinod, Dandugula Sneha Latha

引用次数: 0

Abstract

We developed an efficient mechanochemical method for the synthesis of 1,2-dihydropyridine derivatives from push-pull enamines and tert-propargyl alcohols under ball milling with p-TsOH/HFIP. The reaction proceeds smoothly under metal-free conditions with fast, efficient, and high-yielding synthesis of 1,2-dihydropyridines. The reaction shows excellent atom economy, with a broad substrate generality.

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推拉烯胺与丙炔醇的机械化学环化反应

我们开发了一种以推拉烯胺和叔丙炔醇为原料，在对 TsOH/HFIP 球磨条件下合成 1,2-二氢吡啶衍生物的高效机械化学方法。反应在无金属条件下顺利进行，快速、高效、高产地合成了 1,2-二氢吡啶。该反应显示出优异的原子经济性，并具有广泛的底物通用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.