Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Elisa Chelucci, Giorgia Scarfò, Rebecca Piccarducci, Antonio Rizza, Jonathan Fusi, Francesco Epifani, Sara Carpi, Beatrice Polini, Laura Betti, Barbara Costa, Sabrina Taliani, Vito Cela, Paolo Artini, Simona Daniele, Claudia Martini, Ferdinando Franzoni
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引用次数: 0

Abstract

Physical activity has been demonstrated to improve cognitive function, thereby preventing/slowing neurodegenerative diseases (NDs). Biological responses to physical activity and vulnerabilities to NDs are emerging to be gender-related. Herein, known ND-associated markers (β-amyloid, tau, α-synuclein), main sex steroid hormones, antioxidant responses, and key gene transcription modulators were evaluated in the blood of physically active and sedentary women and men. In our hands, females presented higher basal erythrocytes β-amyloid and α-synuclein amounts than males. Regular physical activity was able to significantly reduce the erythrocyte content of β-amyloid in females and the tau levels in males, suggesting that these differences may be mediated by organizational actions of sex steroid hormones during development. Furthermore, despite a comparable plasma antioxidant capability (AOC) between males and females, in the latter group, physical activity significantly enhances AOC versus peroxynitrite radicals only. Finally, regular physical activity modulated the levels of transcription factor Nrf2 in erythrocytes, as well as the plasma concentration of the microRNA miR-195 and miR-153, suggesting the promotion of antioxidant/autophagic processes associated with ND-related proteins. Overall, these results could shed light on how cerebral adaptations to physical activity differ between males and females, especially with regard to blood accumulation of ND proteins and mechanisms of antioxidant responses to regular exercise.

血液中神经退行性病变相关蛋白的积累和定期体育锻炼抗氧化反应的性别差异
事实证明,体育锻炼可以改善认知功能,从而预防/减缓神经退行性疾病(NDs)。对体育锻炼的生物反应和对 NDs 的易感性正逐渐发现与性别有关。在此,我们对参加体育锻炼和久坐不动的女性和男性血液中已知的 ND 相关标记物(β-淀粉样蛋白、tau、α-突触核蛋白)、主要性类固醇激素、抗氧化反应和关键基因转录调节因子进行了评估。在我们的研究中,女性的基础红细胞β-淀粉样蛋白和α-突触核蛋白含量高于男性。定期体育锻炼能显著降低女性红细胞中的β-淀粉样蛋白含量和男性红细胞中的tau水平,这表明这些差异可能是由发育过程中性激素的组织作用介导的。此外,尽管男性和女性的血浆抗氧化能力(AOC)相当,但在后者群体中,体育锻炼仅能显著增强血浆抗氧化能力而不是过氧化亚硝酸自由基。最后,有规律的体育锻炼调节了红细胞中转录因子 Nrf2 的水平,以及血浆中 microRNA miR-195 和 miR-153 的浓度,这表明体育锻炼促进了与 ND 相关蛋白有关的抗氧化/自噬过程。总之,这些结果可以说明男性和女性大脑对体育锻炼的适应性有何不同,特别是在血液中ND蛋白的积累和定期锻炼的抗氧化反应机制方面。
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来源期刊
Journal of Molecular Neuroscience
Journal of Molecular Neuroscience 医学-神经科学
CiteScore
6.60
自引率
3.20%
发文量
142
审稿时长
1 months
期刊介绍: The Journal of Molecular Neuroscience is committed to the rapid publication of original findings that increase our understanding of the molecular structure, function, and development of the nervous system. The criteria for acceptance of manuscripts will be scientific excellence, originality, and relevance to the field of molecular neuroscience. Manuscripts with clinical relevance are especially encouraged since the journal seeks to provide a means for accelerating the progression of basic research findings toward clinical utilization. All experiments described in the Journal of Molecular Neuroscience that involve the use of animal or human subjects must have been approved by the appropriate institutional review committee and conform to accepted ethical standards.
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