COQ6 defies immune and metabolic expectations

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-11-04 DOI:10.1038/s41590-024-02005-6

Samuel E. Weinberg, Navdeep S. Chandel

引用次数: 0

Abstract

A COQ6 variant increases susceptibility to pneumococcal infection via non-bone marrow-derived cells without affecting ubiquinone synthesis, challenging traditional views on the metabolic role of COQ6 role and opening new avenues for understanding immunometabolic interactions.

Abstract Image

查看原文本刊更多论文

COQ6 不负免疫和新陈代谢的期望

COQ6变体会增加通过非骨髓来源细胞感染肺炎球菌的易感性，但不会影响泛醌的合成，这挑战了人们对COQ6代谢作用的传统看法，为了解免疫代谢相互作用开辟了新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.