A Prospective, Multicenter European Study on the Effects of Anatolian Propolis and Hypertonic Saline Combination Nasal Spray on Allergic Rhinitis Symptoms.

Ear, nose, & throat journal Pub Date : 2024-11-03 DOI:10.1177/01455613241290502

Felicia Manole, Karl Hoermann, Desiderio Passali, Philippe Rombaux, Luisa Maria Bellussi, Michael Rudenko, Mario Milkov, Gabriela Kopacheva-Barsova, Emmanuel Prokopakis, Frédéric Chabolle, Maria Doulaptsi, Cengiz Bal, Cemal Cingi

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Abstract

Objectives: The current study examined the effectiveness of Rhinapi, a hypertonic saline nasal spray with Anatolian propolis added, on allergic rhinitis (AR) symptoms in a European population. Methods: Four hundred and forty AR patients (251 males and 189 females) from various European centers were enrolled. Nasal examination, overall symptom scores, individual AR symptoms (nasal discharge, sneezing, nasal itching, and nasal obstruction), and quality of life (QoL) were assessed before and after 3 weeks of treatment with Rhinapi, the nasal spray made of hypertonic saline with Anatolian propolis added (Bee&You, Istanbul, Turkey). Results: Rhinapi nasal drop use was associated with a substantial decrease (P < .05) in AR symptom ratings, including nasal discharge, sneezing, nasal itching, and nasal obstruction. QoL scores showed a significant improvement (P < .05), and the spray also alleviated swelling and improved concha color (P < .05). Conclusion: Rhinapi, Anatolian propolis-added hypertonic saline nasal spray (Bee&You, Istanbul, Turkey), when used for 3 weeks, reduced AR symptom scores and improved QoL. Both the concha color and the edema were also enhanced.

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关于安纳托利亚蜂胶和高渗盐水鼻腔喷雾剂对过敏性鼻炎症状影响的欧洲多中心前瞻性研究》（Prospective, Multenter European Study on the Effects of Anatolian Propolis and Hypertonic Saline Combination Nasal Spray on Allergic Rhinitis Symptoms）。

研究目的本研究考察了添加了安纳托利亚蜂胶的高渗盐水鼻腔喷雾剂 Rhinapi 对欧洲人群过敏性鼻炎 (AR) 症状的疗效。研究方法来自欧洲不同中心的 40 名过敏性鼻炎患者（251 名男性和 189 名女性）参加了研究。在使用添加了安纳托利亚蜂胶的高渗盐水鼻腔喷雾剂 Rhinapi（Bee&You，土耳其伊斯坦布尔）治疗 3 周前后，对鼻腔检查、总体症状评分、单个 AR 症状（流鼻涕、打喷嚏、鼻痒和鼻塞）和生活质量（QoL）进行了评估。治疗结果使用 Rhinapi 滴鼻剂后，AR 症状评分大幅下降（P < .05），包括流鼻涕、打喷嚏、鼻痒和鼻塞。QoL 评分有明显改善（P < .05），喷雾剂还能减轻肿胀并改善圆锥体颜色（P < .05）。结论使用安纳托利亚蜂胶添加高渗盐水的鼻腔喷雾剂 Rhinapi（Bee&You，土耳其伊斯坦布尔）3 周后，可减少 AR 症状评分并改善 QoL。圆锥体的颜色和水肿也得到了改善。

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Ear, nose, & throat journal

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